Boris Johnson will visit four Brexit-voting Labour-held seats in Humberside and north-east England later, with three days to go before polling day.
In a speech in Sunderland – 61% of which voted to Leave – the PM is expected to tell voters: “The Labour party has let you down.”
He will attack Parliament, saying it has “delayed” and “denied” Brexit.
Mr Johnson will also travel to south-west England, where he will warn against voting for the pro-EU Lib Dems.
Voters go to the polls on Thursday.
Meanwhile, Labour will deliver a budget to “end austerity”, John McDonnell will promise in a speech setting out the party’s priorities for its first 100 days in government.
The shadow chancellor will also set out how he would get “money moving out of Whitehall and the City”.
The Liberal Democrats are, meanwhile, pledging to table legislation to stop Brexit immediately after the election by introducing two draft bills they say would pave the way for another EU referendum.
The first would enable the Electoral Commission to start the necessary consultation around a referendum question and lead campaign designation – and the second would provide a referendum on the government’s Brexit deal versus remaining in the EU.
Lib Dem leader Jo Swinson said: “Every vote for the Liberal Democrats is a vote to stop Boris and stop Brexit.”